Multi-tissue DNA methylation analysis to identify an appropriate surrogate tissue for a unique neurological tissue specific to spina bifida
These results suggest that in the absence of dural tissue, both whole blood and buccal swab samples may be considered as surrogates for dural tissue. The study warrants replication in larger groups to validate findings and may assist researchers restricted to more accessible biospecimens (i.e., blood) to further characterize epigenetic contributors to neural tube defect etiology.
Authors
- Sheikh Muhammad Ekramullah
- Hafiza Sultana Suchanda
- A. Cardenas
- Maitreyi Mazumdar (ORCID: https://orcid.org/0000-0003-0380-2407)
- Sudipta Kumer Mukherjee (ORCID: https://orcid.org/0000-0003-4618-459X)
- Md Nafaur Rahman
- Gwen Tindula (ORCID: https://orcid.org/0000-0002-0819-1732)
- Benjamin C Warf
- Ansar Uddin Ahmed
- Bernardo Lemos
- L M Liang
- Subrata Kumar Biswas
- David C. Christiani
- Joynul Islam
- D. M. Arman
- Md. Ziauddin
Institutions
- Boston Children's Hospital (US)
- Harvard University (US)
- University of Arizona (US)
- University of Connecticut (US)
- National Institute of Neurosciences & Hospital (BD)
- Stanford University (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s13148-026-02061-9
- Citations
- 1
- Primary Topic
- Spinal Dysraphism and Malformations
- Type
- article
- Field-Weighted Citation Impact
- 41.85