Fibroblast Growth Factor 23 Trajectories in Children and Association with CKD Progression
By characterizing longitudinal changes in FGF23 in children with CKD, we find that FGF23 was stable in most children. Membership in the faster-rising FGF23 trajectory groups associates with increased risk of progression to kidney failure. Future studies are needed to investigate whether FGF23 is a modifiable cause or a consequence of CKD progression in children with CKD.
Authors
- Anthony A. Portale (ORCID: https://orcid.org/0000-0003-2054-6898)
- Farzana Perwad (ORCID: https://orcid.org/0000-0001-7983-0127)
- Eva Glenn Lecea
- Furth Sl
- Derek K. Ng (ORCID: https://orcid.org/0000-0001-5878-5101)
- Myles Wolf
- Bradley A. Warady
- Matthew B. Matheson
- Harald Jüppner
- Tamara Isakova
- for the CKiD study investigators
Institutions
- Northwestern University (US)
- Children's Mercy Hospital (US)
- Children's Hospital of Philadelphia (US)
- Harvard University (US)
- Johns Hopkins University (US)
- University of California, Los Angeles (US)
- University of California, San Francisco (US)
- Cornell University (US)
- Massachusetts General Hospital (US)
- Weill Cornell Medicine (US)
Publication Details
- Journal
- Clinical Journal of the American Society of Nephrology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.2215/cjn.0000000954
- Primary Topic
- Parathyroid Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00