PHLDA1 is a shared diagnostic and key mediator of inflammatory fibrosis in heart and kidney
In this study, we identified PHLDA1 as a key driver of fibrosis in both the heart and kidney, acting through IL-1β mediated intercellular crosstalk. These findings indicate PHLDA1 as a potential therapeutic candidate for mitigating fibrosis in cardio-renal syndrome.
Authors
- Lei Hua (ORCID: https://orcid.org/0000-0001-8783-139X)
- Chentong Wang
- Yongshou Tao
- Liangru Shen
Institutions
- Ningbo Medical Center Lihuili Hospital (CN)
- Jiangsu Food and Pharmaceutical Science College (CN)
- Maternal and Child Health Care Hospital of Bao'an (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1765221
- Primary Topic
- IL-33, ST2, and ILC Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00