PTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells

PTTG1 promotes gastric cancer progression by activating the TGF-β/Smad axis to enhance cell proliferation, invasion, and EMT. These findings highlight PTTG1 as a potential diagnostic biomarker and therapeutic target in gastric cancer.

Authors

Chenjie Qiu
Dong Wang (ORCID: https://orcid.org/0000-0001-7877-7440)
Ziwei Xia
Hui Geng

Institutions

Hangzhou Hospital of Traditional Chinese Medicine (CN)

Publication Details

Journal: Hereditas
Published: 2026-02-05
DOI: https://doi.org/10.1186/s41065-026-00647-0
Primary Topic: TGF-β signaling in diseases
Type: article
Field-Weighted Citation Impact: 0.00

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article

PTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells

Chenjie Qiu, Dong Wang, Ziwei Xia, Hui Geng

Feb 5, 2026

Hereditas

TGF-β signaling in diseases

article

PTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells

Chenjie Qiu, Dong Wang, Ziwei Xia, Hui Geng

February 5, 2026article en

Abstract

HereditasVol. 163(1)

Hangzhou Hospital of Traditional Chinese Medicine (CN)

Openalex Percentile: Top 65%

TGF-β signaling in diseases

DOI Open Access PDF OpenAlex

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PTTG1 regulates the TGF-β/Smad pathway to promote the growth and metastasis of gastric cancer cells — Chenjie Qiu, Dong Wang, et al. · Hereditas (2026) | TGRS Research Map | TGRS