Stem cell therapy targets THBS1 to reverse endometrial fibrosis
THBS1 is a key pro-fibrotic factor in IUA, modulating the PI3K/AKT pathway. DMSCs effectively mitigate fibrosis and promote endometrial regeneration, potentially by downregulating THBS1. This study highlights THBS1 as a promising therapeutic target and reinforces the clinical potential of DMSCs for IUA treatment.
Authors
- Xinyu Xu
- Xiaochuan Yu (ORCID: https://orcid.org/0009-0009-3223-3363)
- Lijuan Shi
- Huali Wang (ORCID: https://orcid.org/0000-0002-5579-3592)
- Mingbo Qu
- Yonggang Zhang (ORCID: https://orcid.org/0000-0002-4545-9478)
- Hao Wang (ORCID: https://orcid.org/0000-0001-6881-9977)
- Yating Zhang (ORCID: https://orcid.org/0000-0002-0448-4829)
- Lina Liu
Institutions
- Dalian Medical University (CN)
- Dalian University of Technology (CN)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fcell.2026.1766915
- Primary Topic
- Gynecological conditions and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00