Patient-Derived <i>in Vitro</i> Models Reveal Insights into Medullary Thyroid Cancer Microenvironment and Resistance to Tyrosine Kinase Inhibitors
Our two-step protocol successfully generated primary MTC lines that maintain high plasticity, can be cultivated for several passages, and recreate the heterogeneity observed in patients' tissues. Our model will offer a robust platform for preclinical drug testing and mechanistic studies, addressing a longstanding gap in MTC research. It enables exploration of tumor microenvironment interactions and personalized therapeutic responses, supporting progress beyond current genomic-driven frameworks.
Authors
- Elena Massardi (ORCID: https://orcid.org/0000-0001-7909-4289)
- Viola Ghiandai (ORCID: https://orcid.org/0000-0002-4595-986X)
- Sarah Uraghi
- Carla Maria Colombo (ORCID: https://orcid.org/0000-0003-0716-481X)
- Giacomo Gazzano (ORCID: https://orcid.org/0000-0002-7416-4644)
- Laura Fugazzola (ORCID: https://orcid.org/0000-0001-5372-0982)
- Germano Gaudenzi (ORCID: https://orcid.org/0000-0003-3516-8471)
- Elisa Grassi (ORCID: https://orcid.org/0000-0002-0410-1277)
- Giovanni VITALE
- Davide Gentilini
- Valentina Cirello
- Erika Carbone
- Gianlorenzo Dionigi
Institutions
- University of Milan (IT)
- University of Pavia (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Thyroid
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1177/10507256251408825
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00