Chemoselective 1,2-Sulfonamidoazidation of Styrene via Single-Atom-Site Cobalt Catalysis
Precise control of chemo- and regioselectivity in intermolecular difunctionalization of alkenes remains a long-standing challenge in organic synthesis. Here, we report a heterogeneous cobalt single-atom-site catalyst that enables selective 1,2-sulfonamidoazidation of styrenes. The system features good functional group tolerance and excellent recyclability. By leveraging the characteristics of single-atom-site catalysis, this work provides a valuable platform for achieving highly selective, efficient, and sustainable styrene functionalization.
Authors
- Conghui Tang (ORCID: https://orcid.org/0000-0002-3018-2955)
- Wenxuan Xue (ORCID: https://orcid.org/0000-0003-0931-7867)
- Liming Yang (ORCID: https://orcid.org/0000-0001-7961-4854)
- Mingtao Wu (ORCID: https://orcid.org/0000-0002-7974-682X)
- Professor Dr. M. Beller
- Jing Jia
- Rajenahally V. Jagadeesh
Institutions
- VSB - Technical University of Ostrava (CZ)
- Peking University (CN)
- Leibniz Institute for Catalysis (DE)
- Food and Drug Administration (TH)
- Environmental Technologies (United States) (US)
- State Key Laboratory of Natural and Biomimetic Drugs (CN)
- Huazhong University of Science and Technology (CN)
- Nanjing University (CN)
Publication Details
- Journal
- Journal of the American Chemical Society
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1021/jacs.5c12264
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 45.90