Early Photoreceptor Disruption in Emerging Subretinal Drusenoid Deposits Detected by Adaptive Optics Imaging
High-resolution adaptive optics confocal imaging enables detection of photoreceptor optical property alterations at a stage when SDDs are not yet evident on OCT. This finding underscores the exceptional sensitivity of photoreceptors to minimal structural or functional perturbations during SDD formation and defines an early window for potential intervention.
Authors
- X. Wang
- Shin Kadomoto
- David Sarraf
- Ruixue Liu
- Michael Ip
- SriniVas R Sadda
- Yuhua Zhang
- Sujin Hoshi
Institutions
- University of Tsukuba (JP)
- University of California, Los Angeles (US)
- Kyoto University (JP)
- Doheny Eye Institute (US)
- Steinhauser (Czechia) (CZ)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-04
- DOI
- https://doi.org/10.64898/2026.01.28.26344907
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- W. M. Keck Foundation
- Research to Prevent Blindness