iFIND INH/FQ: a LC-aNAAT assay for rapid simultaneous detection of isoniazid and fluoroquinolone resistance in <i>Mycobacterium tuberculosis</i>
As a low-complexity automated nucleic acid amplification test, the iFIND assay achieves the goal of simultaneously detecting isoniazid and fluoroquinolone resistance in approximately 90 min, perfectly meeting the TPP's core requirements for "rapid" and "simple operation." Its fully integrated system minimizes manual steps and contamination risk, making it highly suitable for use in resource-limited, lower-biosafety-level primary laboratories.
Authors
- Y Q Chen
- Ruida Xing (ORCID: https://orcid.org/0000-0001-9696-0214)
- Hui Xia
- Jinɡjinɡ Li (ORCID: https://orcid.org/0000-0002-7526-5308)
- Yajie Guo
- Yan Li
- Bing Zhao
- Yanlin Zhao
- Jiaojian Zeng
- Yingzi Ma
- Lin Huang
- Huiwen Zheng
- Xichao Ou
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- Taiwan Centers for Disease Control (TW)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1128/spectrum.03743-25
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Chinese Center for Disease Control and Prevention
- Beijing Municipal Health Commission
- Centers for Disease Control and Prevention