Cerebrospinal Fluid Metagenomic Next-Generation Sequencing in Pediatric Central Nervous System Infection: Clinical Experience and Diagnostic Stewardship Strategies
CSF mNGS demonstrated higher diagnostic yield in patients whose specimens showed CSF pleocytosis and in those who had PID consultation. Diagnostic stewardship strategies were applied, including specimen hold approaches and PID consultation.
Authors
- James Gaensbauer (ORCID: https://orcid.org/0000-0002-0732-4150)
- Guyu Li (ORCID: https://orcid.org/0000-0002-0729-8933)
- Emily Puumala (ORCID: https://orcid.org/0009-0008-3371-5877)
- Elizabeth H. Ristagno (ORCID: https://orcid.org/0000-0002-5908-0231)
- Amanda A Rodning
- Patricia J. Simner (ORCID: https://orcid.org/0000-0001-6134-151X)
- Matthew J. Wolf (ORCID: https://orcid.org/0000-0001-8004-4852)
- Z.-L. Zhang (ORCID: https://orcid.org/0009-0006-2355-3232)
- Robin Patel
Institutions
- Mayo Clinic (US)
- Mayo Clinic in Florida (US)
- Berkeley Public Health Division (US)
- University of California, Berkeley (US)
Publication Details
- Journal
- Open Forum Infectious Diseases
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1093/ofid/ofag054
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00