HBr–H <sub>2</sub> O <sub>2</sub> –Promoted Achmatowicz Rearrangement
The Achmatowicz rearrangement enables the oxidative ring expansion of furfuryl alcohols into dihydropyranones, key motifs in natural products. Herein, we report a mild, metal-free method using a HBr-H<sub>2</sub>O<sub>2</sub> system as an inexpensive source of electrophilic bromine species. The optimized conditions accommodate a broad range of primary, secondary, and tertiary furfuryl alcohols, providing a practical approach to access structurally diverse pyranone scaffolds.
Authors
- Jiang‐Fei Li
- Ting Sun (ORCID: https://orcid.org/0000-0003-2178-5209)
- Qin Zhu (ORCID: https://orcid.org/0000-0001-7042-6806)
- Wenchao Zhu
- Shaoyin Wang
Institutions
- Wannan Medical College (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1021/acs.joc.5c02820
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.00