Neuronal VIP wires the intestinal epithelial cell function.
Two studies in Nature Immunology by Jakob, Sterczyk et al. and Pirzgalska et al. show that neuron-derived vasoactive intestinal peptide (VIP) regulates intestinal epithelial differentiation and orchestrates immune responses. Through its receptor VIPR1, VIP restrains secretory lineage expansion, balances type 1 and type 2 immunity, and establishes a neuro-epithelial circuit preserving gut barrier integrity.
Authors
- Valentin Thevin (ORCID: https://orcid.org/0000-0002-0548-1160)
- Ziad Al Nabhani
- Luisa Morelli
Institutions
- Foundation for Biomedical Research (US)
- Tracer Technologies (United States) (US)
- GP Forschungsgruppe (DE)
Publication Details
- Journal
- Open Access CRIS of the University of Bern
- Published
- 2026-02-01
- DOI
- https://doi.org/10.48620/94305
- Primary Topic
- Neuropeptides and Animal Physiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00