Association of Y-chromosomal gr/gr deletions with testicular germ cell tumor: whole-genome analysis of 198,306 individuals
Our analysis suggests gr/gr deletion status alone is likely not predictive of TGCT risk in population-scale analyses of European-like individuals; however, the importance of other proposed determinants of gr/gr deletion impact, including Y-haplogroups and semen phenotype, remains unexplored at scale.
Authors
- Maria Santa Rocca (ORCID: https://orcid.org/0000-0002-4794-9745)
- David J. Vaughn (ORCID: https://orcid.org/0000-0002-7319-7719)
- Zeid Kuzbari
- Giovenale Moirano (ORCID: https://orcid.org/0000-0001-8748-3321)
- Lynn Anson‐Cartwright (ORCID: https://orcid.org/0000-0002-7726-9695)
- S. M. Domchek
- Kevin T. Nead (ORCID: https://orcid.org/0000-0001-9680-8298)
- Cinzia Vinanzi (ORCID: https://orcid.org/0000-0002-3133-7058)
- Charlie F Rowlands (ORCID: https://orcid.org/0000-0001-5333-4846)
- Chey Loveday (ORCID: https://orcid.org/0000-0002-2291-372X)
- A. Ferlin
- Subin Choi (ORCID: https://orcid.org/0009-0002-1947-9966)
- Jérémie Nsengimana
- Beth Torr
- Jenny N. Poynter
- Jourik A. Gietema
- Peter A. Kanetsky
- Benita Weathers
- Darren R. Feldman
- Clare Turnbull
- Sophie Allen
- Anna Gonzalez-Neira
- Csilla Krausz
- Robert J. Hamilton
- John Pluta
Institutions
- University of Minnesota (US)
- Royal Marsden NHS Foundation Trust (GB)
- University Medical Center Groningen (NL)
- Memorial Sloan Kettering Cancer Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Padua (IT)
- Institute of Cancer Research (GB)
- University of Toronto (CA)
- Princess Margaret Cancer Centre (CA)
- Moffitt Cancer Center (US)
- Spanish National Cancer Research Centre (ES)
- Centre for Biomedical Network Research on Rare Diseases (ES)
- Translational Therapeutics (United States) (US)
- Department of Medical Sciences (BY)
- Piedmont Reference Center for Epidemiology and Cancer Prevention (IT)
- University of Florence (IT)
- University of Pennsylvania (US)
- Newcastle University (GB)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-05
- DOI
- https://doi.org/10.64898/2026.02.04.26345360
- Primary Topic
- Testicular diseases and treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- University of Pennsylvania
- Movember Foundation
- Cancer Research UK
- National Institutes of Health