Atherosclerotic Fibrous Plaques in Women Present ECM Remodeling Linked to TGF-β
Women and men with end-stage fibrous atherosclerotic plaques exhibit distinct clinical and molecular profiles. These mechanisms might be candidate pathways to understand plaque erosion from a molecular point of view and may provide promising targets for atherosclerosis therapies, as they account for both sex and plaque phenotype.
Authors
- L. Maegdefessel
- Stephen J. White (ORCID: https://orcid.org/0000-0003-0090-6358)
- Eloi Mili (ORCID: https://orcid.org/0000-0002-9070-9851)
- Daniek Kapteijn
- Denitsa Meteva (ORCID: https://orcid.org/0000-0003-4741-924X)
- Barend Mol
- Tim R. Sakkers (ORCID: https://orcid.org/0000-0003-3505-2110)
- M Mokry
- Ernest Diez Benavente (ORCID: https://orcid.org/0000-0002-4313-4290)
- Kelsey Watts (ORCID: https://orcid.org/0000-0003-4481-6303)
- Marian Wesseling (ORCID: https://orcid.org/0000-0003-4198-3827)
- D. V. de Kleijn
- Gerard Pasterkamp
- Manuel Mayr
- Hanna Winter
- Mete Civelek
- Sander W. van der Laan
- Nicolas Barbera
- R. Noah Perry
- Hester M. den Ruijter
- Inês R. Dias
- Gert J. de Borst
Institutions
- University of California, Los Angeles (US)
- Utrecht University (NL)
- TUM Klinikum (DE)
- University of California System (US)
- University Medical Center Utrecht (NL)
- Humboldt-Universität zu Berlin (DE)
- Lung Institute (US)
- Institute of Human Genetics (PL)
- German Centre for Cardiovascular Research (DE)
- University of Virginia (US)
- Medical University of Vienna (AT)
- Newcastle University (GB)
Publication Details
- Journal
- Circulation Research
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1161/circresaha.125.327624
- Primary Topic
- TGF-β signaling in diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00