Urolithin A alleviates vascular remodeling through mitochondrial SIRT3-mediated SOD2 deacetylation and antioxidation in hypertensive rats
UA attenuates VSMCs proliferation and migration in SHR by increasing mitochondrial SL-SIRT3 level, and subsequent SOD2 deacetylation and mitoROS reduction in SHR. Long-term administration of UA attenuates vascular remodeling, hypertension and oxidative stress in SHR.
Authors
- Jing-Xiao Wang
- Yiming Wang (ORCID: https://orcid.org/0000-0003-2731-0298)
- Xiaoyu Xu (ORCID: https://orcid.org/0000-0002-2377-5330)
- Guo-Qing Zhu
- Fen Zheng
- Min Dai
- Hong-Ke Dong
Institutions
- Nantong University (CN)
- The Affiliated Taizhou People's Hospital of Nanjing Medical University (CN)
- Nanjing Medical University (CN)
Publication Details
- Journal
- Redox Report
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1080/13510002.2026.2622255
- Primary Topic
- Pomegranate: compositions and health benefits
- Type
- article
- Field-Weighted Citation Impact
- 0.00