Prenatal Closure of Myeloschisis vs Myelomeningocele: Insights From the fMMC Consortium Registry
Myeloschisis and myelomeningocele demonstrate distinct clinical profiles. Although patients with myeloschisis may have favorable motor outcomes, they are also characterized by higher rates of CSF leakage, CSF diversion, and tethered cord surgery. These findings highlight the need for lesion-specific prognostication and may inform surgical planning and parental counseling in the context of prenatal spina bifida closure.
Authors
- Joseph B. Lillegard (ORCID: https://orcid.org/0000-0002-1972-5074)
- Alekhya Jampa
- Akos Herzeg (ORCID: https://orcid.org/0000-0002-2061-4099)
- Tim Van Mieghem (ORCID: https://orcid.org/0000-0002-3034-6905)
- Stephen P. Emery (ORCID: https://orcid.org/0000-0002-8539-7566)
- Aimen F. Shaaban (ORCID: https://orcid.org/0000-0002-9459-107X)
- Michael V. Zaretsky (ORCID: https://orcid.org/0000-0001-6465-8846)
- KUOJEN TSAO
- Yair J. Blumenfeld
- Christopher Q. Buchanan
- David S. Hersh (ORCID: https://orcid.org/0000-0003-1177-2201)
- M. Sanz Cortes
- Gregory G. Heuer (ORCID: https://orcid.org/0000-0002-1989-0141)
- Caitlin Clifford
- François I. Luks (ORCID: https://orcid.org/0000-0002-4208-8691)
- Juliana S. Gebb (ORCID: https://orcid.org/0000-0001-5829-1961)
- Julie S. Moldenhauer
- Kelly Bennett
- Ueli Moehrlen
- Shinjiro Hirose
- Amy J. Wagner
- Jena L. Miller
- Mauro H. Schenone
- William H. Goodnight
- Timothy M. Crombleholme
- Amirul Anuar
- Jagruti Anadkat
Institutions
- Northwestern University (US)
- University of North Carolina at Chapel Hill (US)
- Cincinnati Children's Hospital Medical Center (US)
- Mount Sinai Hospital (CA)
- Mayo Clinic (US)
- Children's Hospital of Philadelphia (US)
- Johns Hopkins University (US)
- University of Pittsburgh (US)
- University of California, San Francisco (US)
- Baylor College of Medicine (US)
- University of Zurich (CH)
- Medical College of Wisconsin (US)
- Washington University in St. Louis (US)
- Brown University (US)
- University of Michigan (US)
- Johns Hopkins Medicine (US)
- Society for Maternal-Fetal Medicine (US)
- University of California System (US)
- Minnesota West Community & Technical College (US)
- Children's Hospital Colorado (US)
- University Surgical Associates (US)
- Connecticut Children's Medical Center (US)
- Nemours Children's Health System (US)
- Seattle Children's Hospital (US)
- Hasbro Children's Hospital (US)
- Mayo Clinic in Arizona (US)
- Lurie Children's Hospital (US)
- University Children's Hospital Zurich (CH)
- Children's Minnesota (US)
- Stanford Medicine (US)
- Mayo Clinic in Florida (US)
- Texas Children's Hospital (US)
- Children's Cancer Center (US)
- Johns Hopkins Center for Communication Programs (US)
- St. Mary's Health Center (US)
- Nemours Children's Clinic (US)
- The University of Texas Health Science Center (US)
- Midwest Orthopaedic Research Foundation (US)
- Hartford Financial Services (United States)
- Saint Louis University (US)
- UConn Health (US)
- Vanderbilt University Medical Center (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Neurosurgery
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1227/neu.0000000000003954
- Primary Topic
- Spinal Dysraphism and Malformations
- Type
- article
- Field-Weighted Citation Impact
- 0.00