Patient-reported Vision Quality-of-life in Parkinsonian Syndromes and Ataxias and Association with Clinical Oculomotor Findings
Parkinsonian syndromes and ataxias are associated with substantial VQoL impairment, particularly in visual processing speed. Gaze-evoked nystagmus is a key predictor of reduced VQoL in ataxias, highlighting the functional relevance of fixation instability. Patient-reported outcomes and oculomotor assessments are essential for capturing visual disability in clinical care and trials.
Authors
- R. Ram Manohar
- Anna C. Luddy (ORCID: https://orcid.org/0000-0002-2184-7687)
- A. -M. Wills
- JD Schmahmann
- Faye X. Yang
- Anoopum S. Gupta (ORCID: https://orcid.org/0000-0002-8741-0621)
- Albert Y. Hung
- Christopher D Stephen
Institutions
- Harvard University (US)
- Massachusetts General Hospital (US)
- Centre for Movement Disorders (CA)
Publication Details
- Journal
- medRxiv
- Published
- 2026-02-05
- DOI
- https://doi.org/10.64898/2026.02.03.26345521
- Primary Topic
- Genetic Neurodegenerative Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Massachusetts General Hospital
- Biogen
- Massachusetts Life Sciences Center
- Broad Institute
- National Institutes of Health