Heat stress alters metabolic pathways and nitric oxide signaling in keratinocytes under hyperglycemia
This study is the first to demonstrate heat-induced metabolic changes in keratinocytes involving arginine and NO, highlighting their potential as clinical biomarkers for thermal stress adaptation, with implications for both healthy individuals and diabetic patients.
Authors
- Anni I. Nieminen (ORCID: https://orcid.org/0000-0001-8999-6040)
- Nsrein Ali (ORCID: https://orcid.org/0000-0001-9173-3717)
- I Miinalainen
- Seppo J. Vainio
- Syeda Tayyiba Rahat
Institutions
- University of Helsinki (FI)
- Oulu University of Applied Sciences (FI)
- University of Oulu (FI)
Publication Details
- Journal
- Journal of Diabetes Investigation
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1111/jdi.70256
- Primary Topic
- Thermoregulation and physiological responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Biocenter Finland
- Helsinki Institute of Life Science, Helsingin Yliopisto
- European Regional Development Fund
- Infotech Oulu