TRPM7 Deficiency Protects Against Myocardial Ischemia-Reperfusion Injury by Regulating Intracellular Zn <sup>2+</sup> Homeostasis
TRPM7-mediated intracellular Zn<sup>2</sup><sup>+</sup> release contributes to myocardial I/R injury by triggering apoptotic and pyroptotic cardiomyocyte death. Given that TRPM7 is highly upregulated in patients with ischemic heart failure, our findings suggest that targeting TRPM7 may represent a novel therapeutic strategy for ischemic heart disease.
Authors
- Jiajie Yan (ORCID: https://orcid.org/0000-0003-2434-7175)
- Yibing Qyang (ORCID: https://orcid.org/0000-0002-0332-2449)
- Loren W. Runnels (ORCID: https://orcid.org/0000-0002-2537-7360)
- Xun Ai (ORCID: https://orcid.org/0000-0003-0739-0286)
- Jianlin Feng (ORCID: https://orcid.org/0009-0003-3116-506X)
- Lixia Yue
- Cindy Xintong Li
- Zhichao Yue
- Masayuki Matsushita
- Xin Li
- Xiaohan Li
Institutions
- Johnson University (US)
- Yale Cancer Center (US)
- The Ohio State University Wexner Medical Center (US)
- University of the Ryukyus (JP)
- Yale University (US)
- Shaanxi Research Association for Women and Family (CN)
- Cardiovascular Research Center (BR)
- UConn Health (US)
Publication Details
- Journal
- Circulation
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1161/circulationaha.125.074791
- Primary Topic
- Magnesium in Health and Disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00