ROS-implicated apoptosis in Candida albicans: mechanistic insights into Aureobasidin A's antifungal activity
Beyond its known effect on sphingolipid synthesis, AbA exerts potent antifungal effects, which our data suggest involve the induction of ROS accumulation and subsequent mitochondrial dysfunction, leading to apoptosis. This dual mechanism highlights its promise as a therapeutic candidate, especially against azole-resistant infections.
Authors
- Juan Liao (ORCID: https://orcid.org/0000-0001-9911-518X)
- Yun Huang (ORCID: https://orcid.org/0000-0003-1549-1669)
- Wei Fei
- Jiaxin Yi
- Jun Guo
- Hao Zhou
- Qinghua Zhang
Institutions
- University of Electronic Science and Technology of China (CN)
- Chengdu Medical College (CN)
- Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
- Stomatology Hospital (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fmicb.2026.1725921
- Primary Topic
- Sphingolipid Metabolism and Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00