The Aldehyde Dehydrogenase 2 rs671 Variant Enhances Platelet Activation and Arterial Thrombosis
The <i>Aldh2</i> rs671 variant, which impairs ALDH2 function, increases platelet activation and thrombus formation in vivo through aldehyde accumulation and ROS buildup. Abnormal ACAD10 homeostasis might also contribute to this hyperactivity via enhancing platelet mitophagy. Our findings suggest the potential of ALDH2 as a novel antiplatelet target. Future studies are needed to explore the effects of more aggressive antiplatelet therapy for patients at risk of MI who carry the <i>Aldh2</i> rs671 mutation.
Authors
- Y. Chen
- Xiangkai Zhao (ORCID: https://orcid.org/0000-0001-8874-5354)
- Kehui Yang (ORCID: https://orcid.org/0000-0001-5135-9839)
- Chang Pan (ORCID: https://orcid.org/0000-0003-2098-4265)
- Song Sun (ORCID: https://orcid.org/0000-0003-2382-6481)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Cuiqin Fan
- Hongwei Yue
- Yunyun Guo
- Feng Xu
- Yi Zhang
- Xingming Li
- Cheng Zhang
- Sumei Cui
Institutions
- Shandong University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- World Wide Web Consortium (US)
- Ministry of Education (BD)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Circulation
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1161/circulationaha.125.074318
- Primary Topic
- Alcohol Consumption and Health Effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00