Evaluating the non-specific effects of BCG vaccination on the immune system and serological response to influenza vaccination in the elderly: A randomised controlled trial
In this randomised clinical trial of Danish senior citizens, BCG vaccination did not influence serological response to influenza vaccination or reduce the risk of infection compared with placebo. There was no clear indication of induction of trained immunity.
Authors
- Anne Marie Rosendahl Madsen (ORCID: https://orcid.org/0000-0002-3396-3554)
- Rutger J. Röring (ORCID: https://orcid.org/0000-0003-3921-7541)
- Lene Annette Norberg
- Mette Bliddal (ORCID: https://orcid.org/0000-0002-7637-3730)
- Christine Stabell Benn (ORCID: https://orcid.org/0000-0001-6102-3810)
- Nina Bang
- Frederik Schaltz‐Buchholzer (ORCID: https://orcid.org/0000-0001-7643-8322)
- Peter Aaby
- Ramona Trebbien
- Sören Möller
- Torben Barington
- Mihai G. Netea
- Christian Nielsen
Institutions
- Statens Serum Institut (DK)
- Bandim Health Project (GW)
- Radboud University Nijmegen (NL)
- University of Southern Denmark (DK)
- Odense Municipality (DK)
- Odense University Hospital (DK)
- Radboud University Medical Center (NL)
Publication Details
- Journal
- Vaccine
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1016/j.vaccine.2026.128305
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Odense Universitetshospital