Elevated expression of the NLRP3 inflammasome in post-mortem brain white matter and immune cells in multiple sclerosis
The expression of NLRP3 inflammasome components is dysregulated in MS, both in the brain and in PBMCs. This suggests that uncontrolled NLRP3 inflammasome activity takes place at certain stages of MS.
Authors
- Hugh Kearney (ORCID: https://orcid.org/0000-0003-2320-3487)
- Melody Cui Sun
- Lisa Costelloe
- Eric J. Downer (ORCID: https://orcid.org/0000-0002-6012-2291)
- Jack Prenderville
- Almudena Otálora-Alcaraz (ORCID: https://orcid.org/0000-0002-4813-8119)
- Nicole Hofman
Institutions
- Trinity College Dublin (IE)
- Beaumont Hospital (IE)
- St. James's Hospital (IE)
Publication Details
- Journal
- Multiple Sclerosis and Related Disorders
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1016/j.msard.2026.107040
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Trinity College Dublin
- Irish Research Council