Myeloid-derived PD-L1 characterizes spatially organized immune architecture in colorectal cancer
This exploratory mIF analysis identifies PD-L1 expression predominantly on stromal and immune cells, enriched in IM, particularly on CD163<sup>+</sup> macrophages. High CD8/PD-L1 tumors display spatially organized IM-specific immune niches featuring coordinated effector-regulatory interactions. Comprehensive spatial profiling of IM-enriched populations, including B cells, CD163<sup>+</sup> macrophages, regulatory T cells, and NK cells alongside CD8/PD-L1, may refine patient stratification for immunotherapy in CRC.
Authors
- Filip Van Herpe (ORCID: https://orcid.org/0009-0000-6385-7288)
- Gert De Hertogh (ORCID: https://orcid.org/0000-0001-8494-7725)
- Sylvie Rusakiewicz (ORCID: https://orcid.org/0000-0001-5939-5690)
- Ting Pu
- Sara Verbandt (ORCID: https://orcid.org/0000-0003-1242-3716)
- S. Tissot
- Qian Wu (ORCID: https://orcid.org/0000-0002-4166-7931)
- Gertjan Rasschaert (ORCID: https://orcid.org/0000-0002-7200-5869)
- Allyson Peddle (ORCID: https://orcid.org/0000-0001-7597-5468)
- Xavier Sagaert
- A J L D’Hoore
- Ke Yin
- Sabine Tejpar
- Benyagoub Abdelkader
Institutions
- Centre Hospitalier Universitaire Vaudois (CH)
- KU Leuven (BE)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fimmu.2026.1763068
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00