Oncostatin M upregulates CD73 via the MAPK pathway in keratinocytes to promote an adenosine-dependent anti-inflammatory response in psoriasis
In conclusion, these results provide new insights into the mechanisms by which the CD73/adenosine axis can be modulated in psoriatic conditions and may guide the development of effective strategies to mitigate inflammation.
Authors
- Maria Chiara Monti (ORCID: https://orcid.org/0000-0002-1337-2909)
- Elva Morretta (ORCID: https://orcid.org/0000-0002-7244-0297)
- Caterina Giraulo
- Giacomo De Palma
- Paola Plaitano
- Silvana Morello
- Roberta Esposito
- Carla Cicala
- Christa E. Müller
Institutions
- University of Salerno (IT)
- University of Bonn (DE)
- Drug Discovery Laboratory (Norway) (NO)
- University of Naples Federico II (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fimmu.2026.1698290
- Primary Topic
- Adenosine and Purinergic Signaling
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Università degli Studi di Salerno
- Precursory Research for Embryonic Science and Technology