Overexpression of Rtl1 via synonymous mutation silencing miRNA target site drives skeletal muscle hypertrophy and inflammation in mice
These findings suggest that the overexpression of Rtl1 may contribute to skeletal muscle hypertrophy and induce inflammation in murine models. Consequently, the precise regulation of Rtl1 expression is essential for maintaining skeletal muscle function.
Authors
- Shengsong Xie (ORCID: https://orcid.org/0000-0002-8301-877X)
- Xianwei Song
- Xianghua Xu
- Zihao Zhao (ORCID: https://orcid.org/0000-0001-7497-3276)
- Hao Huang (ORCID: https://orcid.org/0000-0003-0829-2258)
- Lizhu Niu
- Xiaoxuan Fan
- Xuewen Xu
- Yingwei Tong
- Huijun Cheng
Institutions
- Huazhong Agricultural University (CN)
- Nankai University (CN)
- Henan University of Technology (CN)
- Ministry of Agriculture (CA)
- Center of Hubei Cooperative Innovation for Emissions Trading System (CN)
- Ministry of Agriculture and Rural Affairs (CN)
- Henan Agricultural University (CN)
Publication Details
- Journal
- BMC Biology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1186/s12915-026-02534-6
- Primary Topic
- Muscle Physiology and Disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00