Protocols for decolonisation of carbapenem-resistant Enterobacterales and vancomycin-resistant enterococci: a systematic review and meta-analysis
FMT and SDD are promising interventions for CRE decolonisation, with FMT also showing benefit in VRE. The durability of SDD effects appears limited, with significant risk of promoting resistance. Future studies should standardise endpoints, evaluate combination approaches, and explore bacteriophage therapy. We suggest implementing uniform terminology with 'provisional clearance' as a descriptor for eradication at 1 month post intervention and 'enduring clearance' following continuous eradication for 6 months.
Authors
- Slade O. Jensen (ORCID: https://orcid.org/0000-0003-4489-589X)
- Charles E. McCafferty
- James O. Townsend
- Stephen D. Bacchi
Institutions
- New South Wales Department of Health (AU)
- Children's Hospital at Westmead (AU)
- Massachusetts General Hospital (US)
- Australian American Fulbright Commission (AU)
- Ingham Institute (AU)
Publication Details
- Journal
- Journal of Hospital Infection
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1016/j.jhin.2026.01.017
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00