ITIH2 in colorectal cancer metastasis: Weighted Gene Co-expression Network Analysis-guided functional validation
ITIH2 plays a functional role in metastatic behavior and is markedly elevated in liver metastases of CRC. We conclude that ITIH2 may be a novel prognostic biomarker and a potential therapeutic target in patients with CRC who have liver metastases due to its high correlation with poor clinical outcomes and independent prognostic significance for overall survival.
Authors
- Hai-Wen Xu (ORCID: https://orcid.org/0000-0001-7765-254X)
- Xi Zhang (ORCID: https://orcid.org/0000-0002-4638-3997)
- Huayou Luo
- Yan Tian
- Ya-Hui Lin
- Cheng Chen
Institutions
- Kunming Medical University (CN)
- First Affiliated Hospital of Kunming Medical University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1371/journal.pone.0329719
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00