De novo mutation in the ARHGAP32 gene endorses the implication of GTPase-activating proteins (RhoGAP family) in idiopathic autism spectrum disorder
This study identifies shared neurobehavioral features of idiopathic Autism Spectrum Disorder (ASD) associated with <i>de novo</i> LoF mutations in ARHGAP32 and reinforces the involvement of RhoGAP family proteins in neurodevelopmental disorders. Taken together with previous evidence, our data support the role of <i>ARHGAP32</i> as a candidate gene for ASD, expanding the genetic spectrum.
Authors
- Lara Cirnigliaro (ORCID: https://orcid.org/0000-0001-6561-2807)
- C Romano
- Martina Randazzo (ORCID: https://orcid.org/0000-0003-3756-3934)
- Lucia Saccuzzo (ORCID: https://orcid.org/0009-0001-0444-1407)
- Viviana Marzà
- Renata Rizzo
- Maria Perdichizzi
- Marco Fichera
- Rita Barone
Institutions
- University of Catania (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
Publication Details
- Journal
- Frontiers in Psychiatry
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fpsyt.2026.1754241
- Primary Topic
- Autism Spectrum Disorder Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00