In vivo confocal microscopic evaluation of patients with epidermolysis bullosa demonstrates severe loss of corneal nerves

This series identifies profound structural corneal denervation of the central subbasal plexus on IVCM in pediatric RDEB-associated ocular surface disease. The findings support future prospective studies investigating corneal nerve-regeneration and epithelial-stabilization frameworks to preserve long-term visual outcomes in children with RDEB.

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Publication Details

Journal
American Journal of Ophthalmology Case Reports
Published
2026-02-05
DOI
https://doi.org/10.1016/j.ajoc.2026.102519
Primary Topic
Ocular Surface and Contact Lens
Type
article
Field-Weighted Citation Impact
0.00
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article

In vivo confocal microscopic evaluation of patients with epidermolysis bullosa demonstrates severe loss of corneal nerves

Ariana Thompson, Vicki M. Chen, Derya Göksu Fidan, Erin Huynh et al.
American Journal of Ophthalmology Case Reports
Ocular Surface and Contact Lens
article

In vivo confocal microscopic evaluation of patients with epidermolysis bullosa demonstrates severe loss of corneal nerves

Ariana Thompson, Vicki M. Chen, Derya Göksu Fidan, Erin Huynh, Pedram Hamrah, Leyla Yavuz Saricay, Sara Galinko
article en

Abstract

This series identifies profound structural corneal denervation of the central subbasal plexus on IVCM in pediatric RDEB-associated ocular surface disease. The findings support future prospective studies investigating corneal nerve-regeneration and epithelial-stabilization frameworks to preserve long-term visual outcomes in children with RDEB.

American Journal of Ophthalmology Case ReportsVol. 42
Boston University (US), Tufts University (US), Boston Medical Center (US), Boston Children's Hospital (US), Tufts Medical Center (US), Center for Devices and Radiological Health (US), Koç University (TR), Harvard University (US), University of New Mexico (US), University of South Florida (US), Dana-Farber Cancer Institute (US)
Good health and well-being
Openalex Percentile: Top 67%
Ocular Surface and Contact Lens
DOIOpen Access PDFOpenAlex
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In vivo confocal microscopic evaluation of patients with epidermolysis bullosa demonstrates severe loss of corneal nerves — Ariana Thompson, Vicki M. Chen, et al. · American Journal of Ophthalmology Case Reports (2026) | TGRS Research Map | TGRS