Surrogate markers of clinical endpoints in clinical trials of heart failure

In HF trials, most surrogate markers, including NPs and echocardiographic measures were only weakly or moderately correlated with treatment effects on all-cause mortality. There is insufficient evidence to support the use of a single biomarker or echocardiographic measure in regulatory trials of HF.

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Publication Details

Journal
European Journal of Heart Failure
Published
2026-02-04
DOI
https://doi.org/10.1093/ejhf/xuag033
Primary Topic
Heart Failure Treatment and Management
Type
article
Field-Weighted Citation Impact
0.00
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article

Surrogate markers of clinical endpoints in clinical trials of heart failure

N. Raftopulos, Phidias Rueter, T. Hibbert, R. Abdo et al.
European Journal of Heart Failure
Heart Failure Treatment and Management
article

Surrogate markers of clinical endpoints in clinical trials of heart failure

N. Raftopulos, Phidias Rueter, T. Hibbert, R. Abdo, Christian Abhayaratna, Nelson Wang, Sarah Ishak, Muthiah Vaduganathan
article en

Abstract

In HF trials, most surrogate markers, including NPs and echocardiographic measures were only weakly or moderately correlated with treatment effects on all-cause mortality. There is insufficient evidence to support the use of a single biomarker or echocardiographic measure in regulatory trials of HF.

European Journal of Heart Failure
Brigham and Women's Hospital (US), The University of Sydney (AU), Victor Chang Cardiac Research Institute (AU), Royal Prince Alfred Hospital (AU), St Vincent Hospital (US), Westmead Hospital (AU), St Vincent's Hospital Melbourne (AU), St Vincent's Hospital Sydney (AU), St Vincent’s Private Hospital Sydney (AU), The George Institute for Global Health (AU)
Good health and well-being
Openalex Percentile: Top 66%
Heart Failure Treatment and Management
DOISourceOpenAlex
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Surrogate markers of clinical endpoints in clinical trials of heart failure — N. Raftopulos, Phidias Rueter, et al. · European Journal of Heart Failure (2026) | TGRS Research Map | TGRS