Single-Cell Sequencing Reveals Varying Cell-Mediated Immunity Profiles in Individuals With Distinct Antibody Responses Following Ad5-nCoV Booster

These findings elucidate the cellular and molecular mechanisms underlying robust immune responses to the Ad5-nCoV booster, highlighting the critical role of cellular immunity. By integrating humoral and cellular insights, this study offers a new perspective of comprehensive framework for evaluating vaccine efficacy.

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Publication Details

Journal
The Journal of Infectious Diseases
Published
2026-02-03
DOI
https://doi.org/10.1093/infdis/jiag078
Primary Topic
Immune Cell Function and Interaction
Type
article
Field-Weighted Citation Impact
0.00
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article

Single-Cell Sequencing Reveals Varying Cell-Mediated Immunity Profiles in Individuals With Distinct Antibody Responses Following Ad5-nCoV Booster

Weiya Mao, Jiani Wu, Jiahai Lu, ZunFu Ke et al.
The Journal of Infectious Diseases
Immune Cell Function and Interaction
article

Single-Cell Sequencing Reveals Varying Cell-Mediated Immunity Profiles in Individuals With Distinct Antibody Responses Following Ad5-nCoV Booster

Weiya Mao, Jiani Wu, Jiahai Lu, ZunFu Ke, Conghui Liao, Renyun Zha, Xin Guan, Junda Bai, Cheng Guo, Lin Cai, Yuxiang Ye
article en

Abstract

These findings elucidate the cellular and molecular mechanisms underlying robust immune responses to the Ad5-nCoV booster, highlighting the critical role of cellular immunity. By integrating humoral and cellular insights, this study offers a new perspective of comprehensive framework for evaluating vaccine efficacy.

The Journal of Infectious Diseases
Sun Yat-sen University (CN), National Medical Products Administration (CN), Wenzhou Medical University (CN), Shanghai Medical Information Center (CN), Shenzhen Center for Disease Control and Prevention (CN), The First Affiliated Hospital, Sun Yat-sen University (CN), Hainan Medical University (CN)
Openalex Percentile: Top 64%
Immune Cell Function and Interaction
DOISourceOpenAlex
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