Crosstalk Between R-Loops, RNA/DNA Modifications, and Cell Death Dynamics in Canine Models of Retinitis Pigmentosa

Photoreceptor degeneration in xlpra2 and rcd1 is accompanied by overlapping molecular features, including early R-loop- and m⁶A-associated apoptosis with concurrent transcriptional alterations in R-loop-regulatory genes, followed by a progressively R-loop-independent DNA damage response.

Authors

Raghavi Sudharsan (ORCID: https://orcid.org/0000-0001-7839-5178)
Tatyana Appelbaum (ORCID: https://orcid.org/0000-0001-8765-4792)
David A. Smith (ORCID: https://orcid.org/0000-0001-8668-5319)
Kei Takahashi
William A Beltran

Institutions

University of Pennsylvania (US)

Publication Details

Journal: Investigative Ophthalmology & Visual Science
Published: 2026-02-06
DOI: https://doi.org/10.1167/iovs.67.2.20
Primary Topic: Retinal Development and Disorders
Type: article
Field-Weighted Citation Impact: 0.00

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article

Crosstalk Between R-Loops, RNA/DNA Modifications, and Cell Death Dynamics in Canine Models of Retinitis Pigmentosa

Raghavi Sudharsan, Tatyana Appelbaum, David A. Smith, Kei Takahashi et al.

Feb 6, 2026

Investigative Ophthalmology & Visual Science

Retinal Development and Disorders

article

Crosstalk Between R-Loops, RNA/DNA Modifications, and Cell Death Dynamics in Canine Models of Retinitis Pigmentosa

Raghavi Sudharsan, Tatyana Appelbaum, David A. Smith, Kei Takahashi, William A Beltran

February 6, 2026article en

Abstract

Photoreceptor degeneration in xlpra2 and rcd1 is accompanied by overlapping molecular features, including early R-loop- and m⁶A-associated apoptosis with concurrent transcriptional alterations in R-loop-regulatory genes, followed by a progressively R-loop-independent DNA damage response.

Investigative Ophthalmology & Visual ScienceVol. 67(2)

University of Pennsylvania (US)

Good health and well-being

Openalex Percentile: Top 66%

Retinal Development and Disorders

DOI Open Access PDF OpenAlex

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