Telmisartan and nicorandil attenuate Polymyxin B-induced renal injury by modulating NrF2/NQO1, FAS/FASL signaling, and mitigation of P53, Cyt-C, and caspase-3

The renoprotective effects of telmisartan and nicorandil were mediated through modulation of the Nrf2/NQO1 antioxidant pathway and FAS/FASL apoptotic signaling, along with downregulation of renal expression of p53, cytochrome c, and caspase-3. These observations clearly indicate the protective role of both agents against PMB-induced nephrotoxicity.

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Journal
Immunopharmacology and Immunotoxicology
Published
2026-01-02
DOI
https://doi.org/10.1080/08923973.2026.2625046
Primary Topic
Acute Kidney Injury Research
Type
article
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article

Telmisartan and nicorandil attenuate Polymyxin B-induced renal injury by modulating NrF2/NQO1, FAS/FASL signaling, and mitigation of P53, Cyt-C, and caspase-3

Heba M. Mahmoud, Marwa M. Khalaf, Ehab A. M. El-Shoura, Lobna A. Abdelzaher et al.
Immunopharmacology and Immunotoxicology
Acute Kidney Injury Research
article

Telmisartan and nicorandil attenuate Polymyxin B-induced renal injury by modulating NrF2/NQO1, FAS/FASL signaling, and mitigation of P53, Cyt-C, and caspase-3

Heba M. Mahmoud, Marwa M. Khalaf, Ehab A. M. El-Shoura, Lobna A. Abdelzaher, Omnia A. M. Abd EL-Ghafar
article en

Abstract

The renoprotective effects of telmisartan and nicorandil were mediated through modulation of the Nrf2/NQO1 antioxidant pathway and FAS/FASL apoptotic signaling, along with downregulation of renal expression of p53, cytochrome c, and caspase-3. These observations clearly indicate the protective role of both agents against PMB-induced nephrotoxicity.

Immunopharmacology and ImmunotoxicologyVol. 48(1)
Beni-Suef University (EG), Nahda University (EG), Al-Azhar University (ID), Al Azhar University (QA), Assiut University (EG)
Good health and well-being
Openalex Percentile: Top 69%
Acute Kidney Injury Research
DOISourceOpenAlex
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Telmisartan and nicorandil attenuate Polymyxin B-induced renal injury by modulating NrF2/NQO1, FAS/FASL signaling, and mitigation of P53, Cyt-C, and caspase-3 — Heba M. Mahmoud, Marwa M. Khalaf, et al. · Immunopharmacology and Immunotoxicology (2026) | TGRS Research Map | TGRS