<scp>XCR1</scp> <sup>+</sup> Conventional Type 1 Dendritic Cells Exacerbate the Inflammation in Osteogenic Arthritis Through <scp>IL</scp> ‐ <scp>17A</scp> <sup>+</sup> <scp>CD8</scp> <sup>+</sup> T Cells
Thus, cDC1s promote autoimmune reactions and osteoarticular lesions through IL-17A<sup>+</sup>CD8<sup>+</sup> T cells. Targeting cDC1 represents a novel therapeutic target for bone remodeling arthritis.
Authors
- ShuQiong Zhang
- Tonghao Zhang (ORCID: https://orcid.org/0000-0001-6558-6557)
- D. Chen
- Haiguo Yu
- Zhidan Fan
- Zhigui Wu
- Yang Sun
- Qiang Xu
- Hui Liu
- Fenli Shao
Institutions
- Nanjing University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Xuzhou Medical College (CN)
- Peking University (CN)
- Nanjing Children's Hospital (CN)
- Nanjing Drum Tower Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Center for Life Sciences (CN)
Publication Details
- Journal
- Arthritis & Rheumatology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1002/art.70069
- Primary Topic
- Spondyloarthritis Studies and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00