Association between monocyte to high-density lipoprotein cholesterol ratio and stroke prevalence in American adults: A cross-sectional NHANES Study

Among the 28,238 participants included in the study, 805 individuals (2.08%) experienced a stroke. A comprehensive logistic regression analysis demonstrated that each standard deviation (SD) increase in MHR was associated with 20% higher odds of stroke (OR = 1.20, 95% CI: 1.08-1.33, P < 0.05). RCS analysis indicated a linear association between MHR and stroke(P > 0.05). Subgroup and sensitivity analyses consistently demonstrated a significant positive association between MHR and stroke. This national, cross-sectional study demonstrated a linear positive correlation between the MHR and stroke, highlighting its potential utility as an indicator. However, the cross-sectional design precludes causal inference, which requires verification by prospective studies.