Xanthotoxin‐triggered <scp>HR51</scp> suppression derepresses detoxification genes to drive metabolic adaptation in <i>Spodoptera litura</i>
This study uncovers a novel derepression mechanism in which suppression of the transcriptional repressor HR51 alleviates its inhibition on detoxification genes, thereby facilitating S. litura adaptation to xanthotoxin. These findings advance our understanding of insect counter-defense against PSMs and highlight HR51 as a promising molecular target for the development of innovative pest management strategies. © 2026 Society of Chemical Industry.
Authors
- Rui Peng (ORCID: https://orcid.org/0000-0002-9483-6276)
- Xiaodan Huang (ORCID: https://orcid.org/0000-0001-8741-2785)
- Mengqing Deng
- Xiyue Xu (ORCID: https://orcid.org/0009-0004-2526-0797)
- Kai Lǚ
- Xinyu Zhao (ORCID: https://orcid.org/0000-0002-5128-4424)
- Zhiming Yang
- Ziyu He
- Jun Li
Institutions
- Anhui Agricultural University (CN)
Publication Details
- Journal
- Pest Management Science
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1002/ps.70631
- Primary Topic
- Insect-Plant Interactions and Control
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Anhui Agricultural University