Methylalkylation of Unactivated Alkenes by Photoredox/Nickel Catalytic HAT and Radical Selectivity Control
Herein, we report a strategy for the methylalkylation of unactivated alkenes via synergistic photoredox/nickel catalysis. This mild transformation employs di-<i>tert</i>-butyl peroxide (DTBP) as a bifunctional reagent, which serves simultaneously as a hydrogen atom transfer (HAT) reagent and a source of methyl radical, thereby facilitating the coupling of malonate-derived radicals with alkenes. By integrating HAT with radical selectivity control, the method enables the formation of two C(sp<sup>3</sup>)-C(sp<sup>3</sup>) bonds in a single synthetic operation, offering a streamlined route to valuable three-dimensional scaffolds.
Authors
- Yi Wang (ORCID: https://orcid.org/0000-0002-8726-402X)
- Hao-Wen Jiang
- Hui Zhang
- Peng-Fei Xu
Institutions
- Frontier Science Foundation (CH)
- State Key Laboratory of Chemical Engineering (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Organic Letters
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1021/acs.orglett.5c05168
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 0.00