Components of Panax ginseng and Rhodiola rosea regulate mitophagy via the SIRT1/3-PGC-1α-NRF2 pathway to improve myocardial ischemia-reperfusion injury
PRC attenuates MIRI by activating the SIRT1/3-PGC-1α-NRF2 pathway to modulate PINK1/Parkin-dependent mitophagy, thereby restoring mitochondrial homeostasis. Our study elucidates a novel mechanism underlying this natural product combination and highlights the SIRT1/3 axis as a promising therapeutic target for cardioprotection.
Authors
- Dongze Zhang (ORCID: https://orcid.org/0000-0002-5510-5972)
- Lihong Jiang
- Liang Zheng (ORCID: https://orcid.org/0009-0004-3488-2141)
- Yingzi Cui
- Lisha Wang (ORCID: https://orcid.org/0000-0002-6482-1073)
- Yuan He
- Rong He
- Hongyu Wei
- Ming Yao
Institutions
- Changchun University of Chinese Medicine (CN)
- The Affiliated Hospital to Changchun University of Chinese Medicine (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fphar.2026.1716078
- Primary Topic
- Medicinal Plants and Bioactive Compounds
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Jilin Province
- People's Government of Jilin Province
- Education Department of Jilin Province