Multiancestry Genome-Wide Association Study Identifies Variants in a Zinc Finger Gene Cluster as Novel Regulators of HIV Control
Our findings suggest ZNF586 as a novel host factor for HIV-1 control and highlight the role of zinc finger proteins as potential contributors to viral persistence. Although ZNF586 has not previously been linked to HIV pathogenesis, its potential role in maintaining retroviral latency and modulating genomic regulation warrants further investigation.
Authors
- Riley H. Tough
- Jacques Fellay
- Abraham Isaac Awada
- Paul J McLaren
Institutions
- Public Health Agency of Canada (CA)
- University of Manitoba (CA)
- École Polytechnique Fédérale de Lausanne (CH)
- University of Lausanne (CH)
Publication Details
- Journal
- The Journal of Infectious Diseases
- Published
- 2026-02-03
- DOI
- https://doi.org/10.1093/infdis/jiag072
- Primary Topic
- Genetic Associations and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00