Oral immunization with <i>Listeria monocytogenes</i> vaccine enhances immunotherapy for protective immunity in murine models of colorectal cancer
Oral <i>Lm</i>-based cancer vaccines targeting CRC elicit robust, widely disseminated, and persistent tumor-specific immune responses in mice. These vaccines limit CRC development when administered prophylactically and provide tumor control when administered therapeutically with ICI. Thus, oral delivery of <i>Lm</i>-based cancer vaccines coupled with ICI may provide improved control of CRC progression in clinical application.
Authors
- Timothy Chu (ORCID: https://orcid.org/0000-0003-3822-3253)
- Semir Beyaz (ORCID: https://orcid.org/0000-0003-4730-4012)
- Rin YANG
- Yangle Yu
- Y. Zhang
- Charlie Chung (ORCID: https://orcid.org/0000-0003-1566-9498)
- Xinyuan Lei (ORCID: https://orcid.org/0000-0001-5049-6188)
- Brian S. Sheridan (ORCID: https://orcid.org/0000-0002-3299-5888)
- Xinran Li (ORCID: https://orcid.org/0000-0002-3897-640X)
- Khadir A Ozler
- Zhijuan Qiu
- Mami Burgac
- Peter M K Westcott
Institutions
- Cold Spring Harbor Laboratory (US)
- Stony Brook School (US)
Publication Details
- Journal
- Journal for ImmunoTherapy of Cancer
- Published
- 2026-02-01
- DOI
- https://doi.org/10.1136/jitc-2025-011570
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00