Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients

Lymphopenia was common and strongly associated with worse outcomes in hospitalized COVID-19 patients, with impaired recovery particularly evident in those receiving corticosteroids. These findings highlight the value of lymphocyte monitoring to inform tailored immunomodulatory strategies in sepsis and severe viral infections.

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Journal
Intensive Care Medicine Experimental
Published
2026-02-06
DOI
https://doi.org/10.1186/s40635-026-00864-x
Primary Topic
COVID-19 Clinical Research Studies
Type
article
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0.00

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article

Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients

Abdulrahman Almjersah, Hanan Fateena, Maude Bouscambert, Olivier Picone et al.
Intensive Care Medicine Experimental
COVID-19 Clinical Research Studies
article

Immune dysregulation through longitudinal lymphocyte trajectories and their clinical determinants in hospitalized COVID-19 patients

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article en

Abstract

Lymphopenia was common and strongly associated with worse outcomes in hospitalized COVID-19 patients, with impaired recovery particularly evident in those receiving corticosteroids. These findings highlight the value of lymphocyte monitoring to inform tailored immunomodulatory strategies in sepsis and severe viral infections.

Intensive Care Medicine ExperimentalVol. 14(1)
Université Libre de Bruxelles (BE), Inserm (FR), Universidad de La Sabana (CO), University of Brawijaya (ID), Odense University Hospital (DK), University of Oxford (GB), Centre Hospitalier Régional et Universitaire de Nancy (FR), Nova Medical (United States) (US), RSUD Prof. Dr. Saiful Anwar Malang (ID), Hospital of St. Francis Xavier (PT), Oxford Institute for Energy Studies (GB), Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est (FR), Universidade Nova de Lisboa (PT), Université de Lorraine (FR)
Bill and Melinda Gates Foundation, Wellcome Trust, National Institute for Health Research Health Protection Research Unit, National Institute for Health and Care Research, Department of Health and Social Care, University of Oxford, Public Health England, Department for International Development, Medical Research Council
Good health and well-being
Openalex Percentile: Top 64%
COVID-19 Clinical Research Studies
DOIOpen Access PDFOpenAlex
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