ISX9 activates the Wnt/β-catenin signaling pathway and exerts neuroprotective effects in Alzheimer’s disease
Our findings indicate that ISX9 potently activates the Wnt/β-catenin signaling pathway and confers cognitive protection in hippocampal cells and AD mice. This compound may serve as a promising therapeutic agent for the treatment of AD.
Authors
- Jianhong Xiao (ORCID: https://orcid.org/0009-0000-8633-2767)
- Xibao Zhao (ORCID: https://orcid.org/0000-0002-8708-9567)
- Yi LIU
- Mingli Peng
- Yuexuan Chen
- Shanshan Liu
- Desheng Lu
- Shujing Lei
- Qi Sun
- Jiaying Ma
Institutions
- Shenzhen University (CN)
- Shenzhen University Health Science Center (CN)
Publication Details
- Journal
- Alzheimer s Research & Therapy
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1186/s13195-026-01961-5
- Primary Topic
- Wnt/β-catenin signaling in development and cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00