circMFN2 Regulates the IGF2BP3-PDK4 to Ameliorate Pulmonary Hypertension
circMFN2 functions as a hypoxia-responsive regulator that preserves mitochondrial homeostasis by restraining the IGF2BP3-PDK4 axis. Intranasal delivery of R8-circMFN2 establishes a translational potential for noninvasive circular RNA-based therapy to reverse pulmonary vascular remodeling and hemodynamic impairment in PH.
Authors
- Xin Jin (ORCID: https://orcid.org/0000-0002-7271-7655)
- YuAng Cai (ORCID: https://orcid.org/0009-0005-6353-1321)
- Miao Guo (ORCID: https://orcid.org/0000-0002-7080-8510)
- Yijin You
- Shaoyuan Huang
- Ying Zhao
- Shan-Shan Li
Institutions
- Nankai University (CN)
Publication Details
- Journal
- Hypertension
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1161/hypertensionaha.125.25460
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00