Contrasting patterns of leptomeningeal and parenchymal gadolinium extravasation in cerebral amyloid angiopathy: An MRI-based evaluation
Our results suggest that global parenchymal gadolinium extravasation across the BBB is lower in patients with CAA compared with controls. This observation can be explained in terms of limited capillary blood perfusion and/or raising the possibility that vascular amyloid-β deposition impairing molecular transport across the BBB. In contrast, focal leptomeningeal enhancement was higher in CAA, reflecting vessel wall infiltration.
Authors
- M. Schipper (ORCID: https://orcid.org/0000-0003-1463-0997)
- Emma A. Koemans (ORCID: https://orcid.org/0000-0003-0560-8077)
- Sabine Voigt (ORCID: https://orcid.org/0000-0002-5182-6676)
- Whitney M. Freeze (ORCID: https://orcid.org/0000-0001-9418-0214)
- Kanishk Kaushik (ORCID: https://orcid.org/0000-0003-1429-6853)
- Reinier G.J. van der Zwet (ORCID: https://orcid.org/0000-0003-4578-1376)
- Rosemarie van Dort (ORCID: https://orcid.org/0000-0002-7777-3189)
- J. de Jong (ORCID: https://orcid.org/0000-0003-4469-0763)
- Maaike C. van der Plas (ORCID: https://orcid.org/0000-0002-1437-5482)
- Walter Backes
- Hilde van den Brink
- Thijs van Osch
- Susanne J van Veluw
- P H M Voorter
- Marianne AA van Walderveen
Institutions
- University Medical Center Groningen (NL)
- Leiden University Medical Center (NL)
- Maastricht University Medical Centre (NL)
- Maastricht University (NL)
- MaineGeneral Medical Center (US)
Publication Details
- Journal
- International Journal of Stroke
- Published
- 2026-02-05
- DOI
- https://doi.org/10.1177/17474930261424089
- Primary Topic
- Intracerebral and Subarachnoid Hemorrhage Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00