Microbial profiling of urothelial carcinoma and benign bladder tissue from formalin-fixed specimens
This proof-of-concept study suggests that: (1) microbiome sequencing from FFPE TURBT specimens can be used for microbiota assessment and can effectively distinguish UCC from benign pathology. (2) bladder microbiomes are heavily depleted following BCG treatment, indicating therapy-induced microbiome alterations.
Authors
- Stefan J. Green (ORCID: https://orcid.org/0000-0003-2781-359X)
- Jake T. Emerson
- Christopher L. Coogan
- Paolo Gattuso
- Ankur Naqib
- Ali Keshavarzian
- Matt Pearson
Institutions
- Rush University Medical Center (US)
- Rush University (US)
Publication Details
- Journal
- Urologic Oncology Seminars and Original Investigations
- Published
- 2026-02-06
- DOI
- https://doi.org/10.1016/j.urolonc.2026.110997
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00