Incision of the pre-Descemet layer and Descemet membrane affects outflow facility: ex-vivo studies on a human eye perfusion model
Our study suggests that surgical disruption of the PDL and DM results in decreased outflow, which can be due to an alteration in biomechanical properties, with consequent molecular changes in the TM, adversely affecting the resistance to outflow. This could explain why the incidence of raised pressure is greater with penetrating keratoplasty compared to deep anterior lamellar keratoplasty.
Authors
- Prity Sahay (ORCID: https://orcid.org/0000-0003-4574-8437)
- Perla Filippini (ORCID: https://orcid.org/0000-0003-1473-5932)
- Burçin Kepez Yildiz
- Imran Masood
- Harminder Singh Dua
Institutions
- University of Nottingham (GB)
- Institute of Mental Health (GB)
- Birmingham and Midland Eye Centre (GB)
- University of Birmingham (GB)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2026-02-06
- DOI
- https://doi.org/10.3389/fmed.2026.1706969
- Primary Topic
- Glaucoma and retinal disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Glaucoma Foundation