Predictive and Prognostic Value of p16 in Head and Neck Squamous Cell Carcinoma Patients Treated with Molecular Targeted Agents or Immune Checkpoint Inhibitors: Subgroup Analysis of the TRIUMPH Study

Patients with p16 (+) showed longer PFS and OS compared to p16 (-) patients. This suggests that p16 has prognostic and predictive values in HNSCC patients who are treated with MTAs or ICIs.

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Publication Details

Journal
Cancer Investigation
Published
2026-02-06
DOI
https://doi.org/10.1080/07357907.2026.2618577
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
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article

Predictive and Prognostic Value of p16 in Head and Neck Squamous Cell Carcinoma Patients Treated with Molecular Targeted Agents or Immune Checkpoint Inhibitors: Subgroup Analysis of the TRIUMPH Study

Der Sheng Sun, Jung Hye Kwon, B. Keam, Sang Hoon Chun et al.
Cancer Investigation
Head and Neck Cancer Studies
article

Predictive and Prognostic Value of p16 in Head and Neck Squamous Cell Carcinoma Patients Treated with Molecular Targeted Agents or Immune Checkpoint Inhibitors: Subgroup Analysis of the TRIUMPH Study

Der Sheng Sun, Jung Hye Kwon, B. Keam, Sang Hoon Chun, Hyun Chang, hyerim ha, Joo Hang Kim, Jang Ho Cho, Yun-Gyoo Lee, In Gyu Hwang, hwan jung yun, Sung-Bae Kim, Sang Hee Cho, Kyoung Eun Lee, Hyo Jung Kim
article en

Abstract

Patients with p16 (+) showed longer PFS and OS compared to p16 (-) patients. This suggests that p16 has prognostic and predictive values in HNSCC patients who are treated with MTAs or ICIs.

Cancer Investigation
Ulsan College (KR), Ewha Womans University (KR), Chungnam National University (KR), Kosin University Gospel Hospital (KR), Asan Medical Center (KR), Seoul National University Hospital (KR), University of Ulsan (KR), Chonnam National University Hospital (KR), Kangbuk Samsung Hospital (KR), Regional Cancer Center (US), Ewha Womans University Medical Center (KR), The Catholic University of Korea Bucheon St. Mary's Hospital (KR), CHA University Bundang Medical Center (KR), Chungnam National University Hospital (KR), Chonnam National University Hwasun Hospital (KR), Catholic Kwandong University International St. Mary's Hospital (KR), Inha University Hospital (KR), Chung-Ang University Hospital (KR), Hallym University Sacred Heart Hospital (KR), Sungkyunkwan University (KR), Catholic University of Korea (KR)
Good health and well-being
Openalex Percentile: Top 65%
Head and Neck Cancer Studies
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