Region-Specific NRF2 Signaling in HIV-Associated Neurocognitive Disorders: A Transcriptomic and Computational Histology Study
NRF2 signaling in HAND is preserved as a coordinated transcriptional network but is selectively activated in white matter during encephalitic disease, highlighting region- and cell-type-targeted therapeutic opportunities.
Authors
- Paolo Fagone (ORCID: https://orcid.org/0000-0002-6694-1992)
- Michelino Di Rosa (ORCID: https://orcid.org/0000-0002-1837-9325)
- Giuseppe Nunnari (ORCID: https://orcid.org/0000-0002-8113-8452)
- Grazia Scuderi (ORCID: https://orcid.org/0000-0002-4073-8224)
- Serena Spampinato (ORCID: https://orcid.org/0009-0003-0149-2078)
Institutions
- University of Catania (IT)
- Ospedale Garibaldi (IT)
Publication Details
- Journal
- Genes
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3390/genes17020195
- Primary Topic
- Genomics, phytochemicals, and oxidative stress
- Type
- article
- Field-Weighted Citation Impact
- 0.00