High PVR protein expression marks clear cell renal cell carcinoma with metastatic spread
In renal tumors, a preliminary subtype-specific pattern emerged: PVR expression was generally low in clear cell carcinoma but enriched in papillary carcinoma. Notably, in the expanded clear cell cohort all cases with high expression were associated with metastatic progression. These findings highlight PVR in tumor biopsies as a potential prognostic marker in clear cell carcinoma and support its further investigation as a biomarker and therapeutic target in renal cancers.
Authors
- Karmela Miklić
- Guy Cinamon (ORCID: https://orcid.org/0000-0002-6988-1817)
- Paola Kučan Brlić (ORCID: https://orcid.org/0000-0002-9178-9128)
- S. Jonjic
- Mijo Golemac (ORCID: https://orcid.org/0000-0002-4486-1887)
- Suzana Malić
- Ante Jakšić (ORCID: https://orcid.org/0000-0001-6622-9463)
- Pini Tsukerman
- Ema Bellulovich
- Berislav Lisnić (ORCID: https://orcid.org/0000-0002-3977-6004)
- Gordana Đorđević
- Tihana Lenac Rovis
- Dean Markić
- Emina Babarović
- Vesna Šupak Smolčić
Institutions
- University of Rijeka (HR)
- Neoleukin Therapeutics (United States) (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-02-05
- DOI
- https://doi.org/10.3389/fimmu.2026.1754848
- Primary Topic
- Viral Infections and Immunology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Hrvatska Zaklada za Znanost
- European Regional Development Fund